As we begin the second quarter of the 21st century, what do the best medical and social science studies tell us about connections between religion and health? The Religion and Human Flourishing series, a three-part research series by Wheatley Institute, answers this question by synthesizing the findings from Koenig, VanderWeele, and Peteet’s Handbook of Religion and Health (3rd ed., 2024)— a collection of hundreds of rigorous and high-quality studies that make up the most comprehensive and methodologically discerning review on religion and health to date. Part one of Religion and Human Flourishing focuses on religion and mental health, while part three focuses on religion and social health.
This current report, Religion and the Physical Health Connection, represents part two of the series. It specifically examines the relationship between religious involvement and measurable physical health outcomes. Drawing on the most rigorous, high-quality studies that met the Handbook’s stringent inclusion criteria, 876 of 1,069 studies (82%) reported significant findings which identified positive correlations between religion and physical health. In contrast, 124 studies (12%) reported negative associations (for example, unhealthy religious influences), while 69 studies (6%) yielded mixed or complex results. Taken together, among the best available evidence, positive associations outnumber negative ones by roughly 7:1.
The research generally finds significant positive correlations between higher religiosity and better physical health across all 15 of the analyzed health factors. However, the strength of these relationships varies widely depending on the specific phenomenon. Across different areas, the ratio of rigorous studies showing positive (healthy) versus negative (unhealthy) connections ranges from less than 2:1 to as high as 90:1. These findings underscore a consistent conclusion: when studied carefully and rigorously, high religious involvement is significantly associated with more than a dozen measurable benefits for physical health. The strongest positive relationships were observed in connection with cerebrovascular disease (10:1), all-cause mortality and longevity (approximately 15:1), substance abuse and addiction (approximately 43:1), and cigarette smoking (90:1).
In addition, research consistently shows a threshold effect: the benefits of religion concentrate among those with sustained, high engagement. Active participation is linked to better mental and physical health—including lower cancer rates, greater longevity, and stronger marriages and families. Meaningful commitment tends to yield the greatest benefits, typically seen among weekly attenders across ages and faiths. From a health-promotion perspective, this growing body of evidence provides science-based support for active religious involvement, with wide-ranging mental, physical, and relational benefits extending across individuals, families, and communities.
While religion is not a cure-all, and harmful expressions do exist, the overall pattern is neither mixed nor evenly divided. Instead, across hundreds of high-quality studies, positive associations outweigh negative ones by wide margins. As societies confront rising rates of mental illness, addiction, social fragmentation, and family instability, the evidence suggests that religion remains a consequential and often underrecognized contributor to human flourishing. Understanding how, when, and why religion promotes well-being is therefore not only an academic concern, but a matter of broad social importance.
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Main Considerations
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Toggle ItemReligion and Cigarette Smoking
Higher religiosity is overwhelmingly associated with lower rates of cigarette smoking, with positive findings outnumbering negative ones by 90:1—the strongest ratio of any health phenomenon examined in this series. This protective effect likely arises from religious teachings that honor the body as sacred; from strong parental and community modeling; from prosocial peer networks; and via faith-based coping practices that offer healthy alternatives to addiction.
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Toggle ItemReligion and Substance Abuse
Religion exerts one of its strongest protective effects against substance abuse, with 94% of high-quality studies showing lower rates of addiction among the more religious. This protective influence operates through multiple pathways—strengthening internal self-control, fostering prosocial peer and family networks, and even engaging the same neural reward circuits implicated in addiction—thereby reducing both the development and persistence of substance abuse disorders while promoting healthier, more adaptive coping.
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Toggle ItemReligion, Stress, and Immunity
Higher religiosity is linked to stronger immune function and healthier stress regulation (approximately 8:1 positive ratio), supported by lower substance abuse, reduced depression and anxiety, greater social support, and faith-based coping that helps moderate cortisol and enhance resilience.
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Toggle ItemReligion, Heart Disease, and Stroke
Higher religiosity is associated with lower rates of coronary heart disease (approximately 4:1), hypertension (approximately 5:1), and cerebrovascular disease (approximately 10:1). These protective effects appear to operate through biological, psychological, behavioral, and social pathways—reducing anger and stress, strengthening relationships and social capital, and promoting healthier lifestyles that lower cardiovascular and stroke risk. We note that while religion is generally associated with healthier patterns of general disease prevention, detection, and treatment compliance, this domain shows the weakest positive-to-negative ratio (approximately 2:1) among all 15 physical health phenomena.
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Toggle ItemReligion and Alzheimer's
Higher religiosity is associated with lower rates of Alzheimer’s disease and other dementias, with positive findings outnumbering negative ones by nearly 5:1. This protective relationship appears to operate through multiple pathways—including healthier prenatal behaviors, greater social connection, higher rates of volunteering and prosocial activity, better diet and physical health, and reduced loneliness.
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Toggle ItemReligion and Physical Limitations
Higher religiosity is linked to lower levels of chronic pain (approximately 4:1) and physical disability (approximately 5:1), likely due to religion’s promotion of purpose, hope, resilience, and healthy habits that reduce depression and anxiety and support physical and emotional well-being.
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Toggle ItemReligion, Lifestyle, and Health Behaviors
Higher religiosity is linked to healthier lifestyle habits, including greater physical activity (approximately 6:1) and better diet and weight outcomes (approximately 6:1). Religious teachings and dietary codes encourage moderation and purpose, though social traditions involving unhealthy communal meals may occasionally offset these benefits.
Policy Considerations
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Toggle ItemRecognize the importance of religious participation in population health.
Consistent evidence links active religious participation with healthier behaviors, lower addiction rates, reduced stress, and greater longevity. Public health frameworks should acknowledge the role of personal faith engagement as a meaningful factor influencing individual, familial, and community well-being.
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Toggle ItemEncourage faith-sensitive and culturally competent care.
Health and social service professionals should be equipped to understand how spiritual beliefs and religious practices affect coping, treatment adherence, and recovery. Integrating faith literacy into professional training can strengthen trust, engagement, and outcomes—without compromising critical health care or clinical standards. Such efforts would empower health care workers to better treat and care for the “whole patient.” Most patients value this aspect of care, but few physicians are trained or experienced in this aspect, aside from palliative care specialists.
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Toggle ItemSupport research and evidence-based partnerships.
Continued funding for rigorous, longitudinal research is needed to clarify how religion influences health through biological, psychological, and social pathways. A new generation of studies can build on strong existing evidence connecting religiosity with lower rates of cancer, stroke, and heart disease—helping identify the mechanisms through which faith contributes to physical health and longevity.
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Toggle ItemEngage faith organizations and communities as key partners in health promotion.
Religious organizations and community-based faith groups should be recognized as vital collaborators in advancing public health. Cooperative engagement with these networks can strengthen prevention efforts, expand outreach, and foster holistic approaches to community well-being.
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Toggle ItemAdvocate for policies and practices that build religious pluralism.
The benefits from religious living identified in this report are dependent upon the ability of individuals and groups to freely practice and live out their specific faith commitments. Legal and cultural norms that protect the right of religious freedom for all and recognize the benefits that religious life and commitments bring to individuals and society as a whole will enhance the likelihood of society experiencing such benefits.
Read part one of the series, The Religion and Mental Health Connection
About the Authors
Loren D. Marks is a Professor in the School of Family Life at Brigham Young University and a Wheatley Institute Affiliate Scholar.
Harold G. Koenig is a Professor of Psychiatry and Behavioral Sciences at Duke University Medical Center and a leading authority on religion and health.
They are joined by co-authors Shima B. Baughman, Jared R. Robbins, Paul W. Lambert, and Elijah L. Nevares.